#Publications

2015

  • Stefan, E.; Taylor, R. E. “1,5-Hydride Transfer Protocol for the Synthesis of beta-Branched Polyketide Structural Units” Tetrahedron Lett. 2015, 56, 3416-3419.
  • Larsen, E.; Wilson, M. R.; Taylor, R.E. “Conformation-Activity Relationships in Polyketide Natural Products” Nat. Prod. Rep. 2015, 32, 1183-1286.
  • Naini, A.; Muthukumar, Y.; Raja, A.; Franke, R.; Smith, III, A. B.; ; Taylor, R.E.; Sasse, F.; Kalesse, M. “The Synthesis of Desepoxy-isotedanolide and its Biological Evaluation in Comparison with Desepoxy-tedanolide” 2015, 54, 6935-6939.
  • Chang, C.-F.; Stefan, E.; Taylor, R.E. “Total Synthesis and Structural Reassignment of Lynbyaloside C Highlighted by Intermolecular Ketene Esterfication” Chem. Eur. J. 2015, 21, 10681-10686.

2014

  • Stevens, D. C.; Young, J.; Carmichael, R.; Tan, J.; R. E. “Draft Genome Sequence of Gephyronic Acid Producer Cystobacter violaceus Strain Cb vi76” Genome A 2014, 2, e01299-14.
2013
  • Young, J.; Stevens, D. C; Carmichael, R.; Tan, J.; Rachid, S.; Boddy, C. N.; Müller, R.; Taylor, R. E. “Elucidation of Gephyronic Acid Biosynthetic Pathway Revealed Unexpected SAM Dependent Methylations” J. Nat. Prod. 201376, 2269-2276.
  • Larsen, E.; Wilson, M. R.; Zajicek, J.; Taylor, R. E. “Conformational Preferences of Zampanolide and Dactylolide” Org. Lett. 2013, 15, 5246-5249.
  • Stefan, E.; Nalin, A. P.; Taylor, R. E. “Concise Enantioselective Synthesis of Diospongins A and B” Tetrahedron 2013, 69, 7706-7712.
  • Wilson, M. R.; Taylor, R. E. “ Strained Alkenes in Natural Product Synthesis” Angew. Chem. Int. Ed. 2013, 52, 4078-4087.
  • Muthukumar Y.; Roy, M.; Raja, A.; Taylor, R. E.; Sasse, F. “The Marine Polyketide Myriaporone 3/4 Stalls Translation by Targeting the Elongation Phase” ChemBioChem 2013, 14, 260-264.

2012

  • Stefan, E.; Taylor, R. E. “Stereoselective Synthesis of the C9–C19 Fragment of Lyngbyaloside B and C via Ether Transfer” Org. Lett. 2012, 14, 3490-3493.
  • Wilson, M. R.; Taylor, R. E. “Toward an Enantioselective Synthesis of (−)-Zampanolide: Preparation of the C9–C20 Region” Org. Lett. 2012, 14, 3408-3411.
  • Zhao, Z.; Taylor, R. E. “Rapid Access to Conformational Analogues of Peloruside A” Org. Lett. 2012, 14, 669-671.

2011

  • Anderl, T.; Nicolas, L.; Münkemer, J.; Muthukumar, Y.; Baro, A.; Frey, W.; Sasse, F.; Taylor, R. E. Laschat, S.; “Synthesis and Biological Evaluation of Gephyronic Acid Derivatives – Initial Steps Toward Identification of the Biological Target of Polyketide Inhibitors of Eukaryotic Protein Synthesis” Eur. J. Org. Chem. 2011, , 3387-3396.
  • Begaye, A.; Trostel, S.; Zhao, Z.; Taylor, R. E.; Schriemer, D. C.; Sackett, D. L. “Mutations in the beta-tubulin binding site for peloruside A confer riesistance by targeting a cleft significant in sidechain binding” Cell Cycle 2011, 10:19, 3387-3396.
  • Anderl, T.; Nicolas, L; Mükemer, J.; Baro, A.; Sasse, F.; Steinmetz, H.; Jansen, R.; Höfle, G.; Taylor, R. E.; Laschat, S. “Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid” Angew. Chem. Int. Ed. 2011, 50, 942-945.
  • Nicolas, L; Anderl, T.; Sasse, F.; Steinmetz, H.; Jansen, R.; Höfle, G.; Laschat, S.; Taylor, R. E. “Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid” Angew. Chem. Int. Ed. 2011, 50, 938-941.
  • Anderl, T.; Nicolas, L; Mükemer, J.; Baro, A.; Sasse, F.; Steinmetz, H.; Jansen, R.; Höfle, G.; Taylor, R. E.; Laschat, S. “Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid” Angew. Chem. Int. Ed. 2011, 50, 942-945.

2010

  • Liu, K.; Arico, J. W.; Taylor, R. E. “Application of Stereoselective Ether Transfer to the Synthesis of Isotactic Polyethers” J. Org. Chem. 201075, 3953-3957.

2009

  • Frein, J.D.; Taylor, R. E.; Sackett, D.L. “New Sources of Chemical Diversity Inspired by Biosynthesis: Rational Design of a Potent Epothilone Analogue” Org. Lett. 2009, 11, 3186-3189.
  • Daly, E., Taylor, R. E ““Entropy and Enthalpy in the Activity of Tubulin-based Antimitotic Agents” Curr. Chem. Biol. 2009, 3, 367-379.
  • Taylor, R. E.; Diene, C. R.; Daly, E. M. “46.11 Synthesis of 1,3-Dienes by Isomerization of Unconjugated Dienes, Allenes, and Alkynes” in Houben-Weyl Science of Synthesis; V. H. Rawal and S. A. Kozmin, Eds.;  G. Thieme Verlag, Stuttgart, 2009, Vol. 46, 549-584.

2008

  • Kartika, R.; Gruffi, T. R.; Taylor, R. E. “Efficient Total Synthesis of Neopeltolide Macrolactone Highlighted by Ether Transfer” Org. Lett. 2008, 10, 5047-5050.
  • Young, J.; Taylor, R. E. “Evolution of Polyketides: Post-PKS Processing in the Formation of Spiroketals” Nat. Prod. Rep. 2008, 25, 651-655.
  • Huzil, J. T.; Chik, J. K.; Slysz, G. W.; Freedman, H.; Tuszynski, J.; Taylor, R. E.; Sackett, D. L.; Schriemer, D. C. “A Unique Mode of Microtubule Stabilization Induced by Peloruside A” J. Mol. Biol. 2008, 378, 1016-1030.
  • Taylor, R. E.; Zhao, Z.; Wünsch, S. “Synthetic Efforts Towards Peloruside A” Comptes Rendus de l’Académie des Sciences – CHIMIE 2008, 11, 1369-1381.
  • Taylor, R. E. “Tedanolide and the Evolution of Polyketide Inhibitors of Eukaryotic Protein Synthesis” Nat. Prod. Res. 2008, 25, 854-861.
  • Kartika, R.; Frein, J. D.; Taylor, R. E. “Electrophilone-Induced Ether Transfer: Stereoselective Synthesis of 2,6-Disubstituted-3,4-Dihydropyrans” J. Org. Chem. 2008, 73, 5592-5594.

2007

  • Kartika, R.; Taylor, R. E. “Electrophile Induced Ether Transfer: Stereoselective Synthesis of 2,4,6-Trisubsituted Pyrans” Angew. Chem. Int. Ed. 2007, 46, 6874-6877.
  • Daly, E. M.; Taylor, R. E. “Recent Applications of the Nozaki-Hiyama Kishi Reaction in Natural Product Synthesis” Chemtracts 2007, 20, 1-8.
  • Kartika, R.; Taylor, R. E. “Electrophile Induced Ether Transfer: An Expedient Route to 2-Cyanotetrahydrofurans” Heterocycles 2007, 74, 447-459.
  • Melancon, B.; Perl, N.; Taylor, R. E. “Competitive Cationic Pathways and the Asymmetric Synthesis of Aryl-Substituted Cyclopropanes” Org. Lett. 2007, 9, 1425-1428.
  • Tung, J. C.; Chen, W.; Taylor, R. E.; Fields, S. C.; Dent, W. C.; Green, F. R. “Towards the Synthesis of the Cornexistins” Synthesis, 2007, 2388-2396.

2006

  • Kartika, R., Taylor, R. E. “An Exhaustive Hydrogenation Strategy to Bicyclic Alkaloids” Chemtracts 2006, 19, 385-390.
  • Hines, J.; Roy, M.; Cheng, H.; Agapakis, C. M.; Taylor, R. E.; Crews, C. M. “Myriaporone 3/4 SAR Studies Reveal a Novel Pharmacophore Targeting Eukaryotic Protein Synthesis” Molecular Biosystems 2006, 2, 371-379. [Highlighted on the cover.]Roy, M.; Taylor, R. E. “Tris(dimethylamino)sulfonium Difluorotrimethyl silicate“ In Encyclopedia of Reagents for Organic Synthesis; Fuchs, P. L., Ed.; Wiley: New York, in press.
  • Liu, K.; Taylor, R.  E.; Kartika, R. “Electrophile-Induced Ether Transfer: A New Approach to Polyketide Structural Units” Org. Lett. 2006, 8, 5393-5395.

2005

  • Jin, M.; Taylor, R. E. “The Total Synthesis of Peloruside A” Org. Lett. 20057, 1303-1305
  • Paquette, W. D.; Taylor, R. E. “Conformationally Biased Macrocyclizations” Chemtracts 200518, 584
  • Taylor, R. E.; Fleming, K. N.; Hearn, B. R. “Total Synthesis of Myriaporones 1, 3, and 4” In Strategies and Tactics in Organic Synthesis; M. Harmata, Ed.; Elsevier: Amsterdam, 2005; Volume 6, 246-268.

2004

  • Risatti, C. R.; Taylor, R. E. “Biomimetic Synthesis of Polycyclic Natural Products from Polyolefinic Precursors” Chemtracts 2004, 83-91.
  • Yuan, H.; Junker, B.; Helquist, P.; Taylor, R. E. “Synthesis of Anti-Angiogenic Isocoumarins” Current Organic Synthesis 20041, 1-9.
  • Taylor, R. E.; Chen, Y.; Galvin, G. M.; Pabba, P. “Conformation-Activity Relationships in Polyketide Natural Products. Towards the Biologically Active Conformation of Epothilone” Org. Biomol. Chem. 20042, 127-132.
  • Paquette, W. D.; Taylor, R. E. “Enantioselective Preparation of the C1-C11 Fragment of Apoptolidin” Org. Lett. 20046, 104-106.
  • Suckow, M. A.; Gutierrez, L. S.; Risatti, C. A.; Wolter, W. R.; Taylor, R. E.; Pollard, M.; Navarri, R. M.; Castellino, F. J.; Paoni, N. F. “The Anti-ischemia Agent Ranolazine Promotes the Development of Intestinal Tumors in APC(Min/+) Mice” Cancer Lett. 2004209, 165-169.
  • Fleming, K. N.; Taylor, R. E. “Total Synthesis and Stereochemical Assignment of Myriaporones 1, 3, and 4” Angew. Chem. Int Ed. 2004, 43, 1728-1730.
  • Risatti, C. A.; Taylor, R. E. “Enantioselective Synthesis of Cyclopropanes via Aldehyde Homologation” Angew. Chem. Int Ed. 2004, 43, 6671-6672.

2003

  • Taylor, R.E; Risatti, C. A.; Engelhardt, F. C.; Schmitt, M. J. “Cyclopropane Structural Units from Homoaldol Adducts” Org. Lett20035, 1377-1379.
  • Vitale-Brown, A. Taylor, R. E. “Lewis Acid-Induced Epoxide Rearrangements” Chemtracts 2003, 254-257.
  • Yoshimura, F.; Rivkin, A.; Gabarda, A. E.; Chou, T.-C.; Dong, H.; Sukenick, G.; Morel, F.F.; Taylor, R. E. Danishefsky S. J. “Synthesis and Conformational Analysis of (E)-9,10-Dehydro Epothilone B. A Suggestive Linkage Between Observations in the Chemistry and Biology of Epothilones.” Angew. Chem. Int. Ed. 200342, 2518.
  • Taylor, R. E. Engelhardt, F. C. “Biosynthetic Inspirations: Cationic Approaches to Cyclopropane Formation” Tetrahedron 200359, 5623-5634.
  • Taylor, R. E.; Jin, M. “Towards the Total Synthesis of Peloruside A: Enantioselective Preparation of the  C8-C24 Region” Org. Lett. 20035, 4959-4961.
  • Taylor, R. E.; Chen, Y.; Beatty, A.; Myles, D. C.; Zhou, Y. “Conformation-Activity Relationships in Polyketide Natural Products. A New Perspective on the Rational Design of Epothilone Analogues” J. Am. Chem. Soc. 2003125, 26-27.

2002

  • Taylor, R. E.; Hearn, B. R.; Ciavarri, J. C. “A Divergent Approach to Tedanolide and Myriaporone: Completion of the Carbon Skeleton of Myriaporone 1.” Org. Lett20024, 2953.
  • Taylor, R. E. “Synthetic Methods for Chemical Diversity Inspired by Natural Products” Natural Product Chemistry at the Turn of the Century2002, (eds. Rahman, Choudary, Khan; Print Arts, Karachi) p. 89.

2001

  • Taylor, R. E.; Engelhardt, F. C.; Schmitt, M. J.; Yuan, H. “Synthetic Methods for the Construction of Structurally Diverse Cyclopropanes” J. Am. Chem. Soc. 2001, 123, 2964.
  • Taylor, R. E.; Chen, Y. “The Total Synthesis of Epothilones B and D” Org. Lett. 2001, 3, 2221.
  • Engelhardt, F. C.; Schmitt, M. J.; Taylor, R. E. “Kinetically Controlled Cross-Metathesis Reaction with High E-Olefin Selectivity” Organic Lett. 2001, 3, 2209.
  • Taylor, R. E. “The Organic Chemist’s Newswire” (journal review) Nature 2001, 413, 678-679.

2000

  • Taylor, R. E.; Schmitt, M. J.; Yuan, H. “Structural Diversity Based on Cyclopropane Scaffolds” Org. Lett20002, 601.

1999

  • Taylor, R. E.; Zajicek, J. “The Conformational Properties of Epothilone” J. Org. Chem1999, 64, 7224.
  • Taylor, R. E; Ciavarri, J. P. “2-Bromo-allyl Acetate.  A Useful Structural Unit for Sequential Carbon–Carbon Bond Formation” Org. Lett. 19991, 467.
  • Taylor, R. E.; Engelhardt, F. C.; Yuan, H. “Oligocyclopropane Structural Units from Cationic Intermediates” Org. Lett19991, 1257.

1998

  • Patterson, S.; Smith, B. D.; Taylor, R. E.  “Tuning the Affinity of a Synthetic Sialic Acid Receptor Using Combinatorial Chemistry” Tetrahedron Lett. 199839, 3111.
  • Taylor, R. E.; Ciavarri, J. P.; Hearn, B. R. “A Divergent Approach to the Myriaporones and Tedanolide: Enantioselective Preparation of the Common Intermediate” Tetrahedron Lett.  199839, 9361.
  • Taylor, R. E.; Galvin, G. M.; Hilfiker, K. A.; Chen, Y. “A Formal Total Synthesis of Epothilone A: Enantioselective Preparation of the C1-C6 and C7-C12 Fragments” J. Org. Chem199863, 9580.

1997

  • Taylor, R. E.; Haley, J. “Towards the Synthesis of Epothilone A: Enantioselective Preparation of the Thiazole Sidechain and Macrocyclic Ring Closure” Tetrahedron Lett. 1997, 38, 2061.
  • Taylor, R. E.; Ameriks, M. K.; LaMarche, M. J. “A Novel Approach to Oligocyclopropane Structural Units” Tetrahedron Lett. 1997, 38, 2057.
  • Patterson, S.; Smith, B. D.; Taylor, R. E. “Fluorescent Sensing of Ribonucleoside 5′-Triphosphate” Tetrahedron Lett. 199738, 6323